Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women / Infecção por Helicobacter pylori e sintomas gastrointestinais em mulheres grávidas chilenas

Objective: the aim of this research was to determine the prevalence of Helicobacter pylori infection on Chilean pregnant women and its relationship with the appearance and severity of hyperemesis and dyspepsia. Methods: quantitative study of prevalence in a transversal cut with variable analysis. The sample was taken from 274 Chilean pregnant women from the Bío Bío province through vein puncture between June and December, 2005. Pregnant women were informed of this study, interviewed and signed an informed consent. The samples were processed using ImmunoComb II Helicobacter pylori IgG kit. Statistical analysis was performed by means of the Statistical Package for Social Sciences (SPSS) Program. Results: out of the total number of pregnant women, 68.6% showed infection by Helicobacter pylori. 79.6% of the total sample had symptoms of dyspepsia, and 72.5% of this group presented Helicobacter pylori infection. 12.4% showed pregnancy hyperemesis; among them, 79.4% were infected with Helicobacter pylori. 73.4% of the pregnant women that showed gastric discomfort during the first three months had Helicobacter pylori infection. 53.7% of them continued with gastric discomfort after the first three months; of those, 95.8% were infected. Helicobacter pylori infection was present only in 1.5% of pregnant women without gastric discomfort. Conclusion: both, gastric discomfort of pregnant women and the continuity of severe symptoms of dyspepsia and hyperemesis after the first three months of gestation are significantly correlated with Helicobacter pylori infection. .

Objetivo: o objetivo desta investigação foi determinar a prevalência da infecção por Helicobacter pylori em mulheres grávidas chilenas e a sua relação com o aparecimento e agravamento de hiperêmese e dispepsia. Métodos: estudo de prevalência, quantitativo de coorte transversal com análise de variáveis. A amostra foi tomada através de punção venosa em 274 mulheres grávidas chilenas, da província de Bío Bío, nos meses de junho a dezembro de 2005. As mulheres que participaram foram informadas, assinaram um consentimento e responderam uma pesquisa. As amostras foram processadas usando o kit ImmunoComb II Helicobacter pylori IgG. A análise estatística foi realizada com o programa Statistical Package for Social Sciences (SPSS). Resultados: do total de mulheres pesquisadas, 68,5% apresentam infecção por Helicobacter pylori. Do total, 80,7% tiveram sinais de dispepsia; dessa porcentagem, 72,5% apresentaram infecção por Helicobacter pylori. Uma porcentagem de 12,6% das pacientes apresentou hiperêmese gravídica; dessas, 79,4% tiveram a infecção. Do total das mulheres grávidas com moléstias gástricas no primeiro trimestre de gravidez, 73,4% registraram infecção por Helicobacter pylori. Uma porcentagem de 53,7% continuou com moléstias gástricas depois do primeiro trimestre e dentro desse grupo 95,8% tiveram a infecção. Infecção por Helicobacter pylori estava presente em apenas em 1,5% das mulheres grávidas sem desconforto gástrico. Conclusão: as moléstias gástricas das mulheres grávidas e o agravamento dos sinais de dispepsia e hiperêmese depois do primeiro trimestre de gravidez estão correlacionados significativamente à infecção por Helicobacter pylori. .

Risk factors in early pregnancy complications

To determine the underlying risk factors in early pregnancy complications and outcome. Case series. This study was conducted at the Department of Obstetrics and Gynaecology Unit-IV, Liaquat University of Medical and Health Sciences, Jamshoro, from July 2007 to June 2008. All the women with first trimester pregnancy with different complications were included in this study while those women with uneventful first trimester were excluded. The inducted women were registered on pre-designed proforma. Studied Variables including demographic details, gestational period, type of complications, risk factors, treatment and outcome. The data was expressed in terms of mean and percentages with a confidence interval of 95%. Analysis was done on SPSS version 14. Out of a 204 total admissions, 115 [56.37%] patients had different early pregnancy complications. Their mean age was 29.4+6.8 years. Commonest complications found were abortion in 88 [76.52%] cases. The underlying risk factors found in abortion were antiphospholipid syndrome in 5 [5.68%] cases, Diabetes mellitus in 8 [9.09%] cases, hypertension in 16 [18.18%] cases, and polycystic ovarian syndrome and infection in 11 [12.5%] cases each. Most of the cases 69 [60%] were treated by minor surgical procedures, and 22 [19.13%] cases responded with conservative medical therapy. Outcome were anaemia in 92 [79.3%] cases, psychological upset in 72 [62.1%], infection in 55 [44%] cases and coagulopathy in 9 [7.8%] cases. Abortion was found as the most frequent early pregnancy complication and the most frequent underlying risk factor was hypertension. Outcome included anaemia, psychological upset and infection

Hiperemese gravídica / Hyperemesis gravidarum

Abordam-se, através de extensa revisäo de literatura, os aspectos controvertidos relacionados à hiperemese gravídica (HG), principalmente quanto à incidência e etiopatogenia. Dentre inúmeras teorias aventadas para explicar a gênese da HG, sobressaem-se os fatores endócrinos e psicossomáticos. O diagnóstico da HG é feito baseado em dados clínicos e por exclusäo, uma vez que inúmeras patologias podem cursar com náuseas e vômitos na gravidez. Näo existem alteraçöes anátomo-patológicas específicas para esta afecçäo. A mortalidade por HG constitui na atualidade um evento de exceçäo. No que se refere à terapêutica, aspectos ligados à hidrataçäo, esquema dietético, sedaçäo, correçäo de distúrbios ácido-básicos e eletrolíticos, amparo psíquico e aborto terapêutico säo detalhadamente abordados